Resistance Is Not Futile: The Role of Quorum Sensing Plasticity in Pseudomonas aeruginosa Infections and Its Link to Intrinsic Mechanisms of Antibiotic Resistance
Bacteria use a cell-cell communication process called quorum sensing (QS) to orchestrate collective behaviors.QS relies on the group-wide detection of extracellular signal molecules called autoinducers (AI).Quorum sensing is required for virulence and biofilm formation in the human pathogen Pseudomonas aeruginosa.In P.aeruginosa, LasR and RhlR are